Synthetic bone graft substitutes

Synthetic bone graft substitutes have been employed over the past 50 years as biomaterials for bone regeneration. They are indicated for bone loss reconstruction procedures and more specifically in the filling of bone defects of traumatic, degenerative, pathological, or surgical origin.

NuvaBone is an innovative line of synthetic bone graft substitutes which is based on nano-structured biomimetic hydroxyapatite, for application in orthopaedics, traumatology, spine, and neurosurgery.

NuvaBone hydroxyapatite is a calcium-phosphate biomaterial equivalent to the mineral matrix of human bone, both in chemical composition and in structure, with the Ca/P ratio of 1.67.

The porous and interconnected structure of the NuvaBone hydroxyapatite offers optimal osteoconductive activity, promoting cell penetration and colonization, circulation of nutrients, and rapid vascularization, also allowing its complete degradation by osteoclasts and a whole remodeling into new vital bone tissue.

NuvaBone is available in different formats to allow its application in various bone loss conditions.

Bone Graft Substitute - Granules

NuvaBone Dense Granules and Porous Chips

These are available with granulometry 1-2 mm in different bottle sizes from 2,0 cc to 50 cc.  Dense granules are compact and similar to human cortical bone; their remodeling time is slower than porous chips, which look like cancellous bone. They can be mixed or associated with biological fluids or au­tologous tissues and used in combination with antibiotics too.

Both formats allow for the filling of small and medium-sized irregular bone defects. They are indicated for the filling of peri-prosthetic defects, post-extraction device sockets, but also for the stuffing of vertebral cages and cavitary bone defects.

Bone Graft Substitute Chips
Bone Graft Substitute Paste

NuvaBone Injectable paste

This Injectable paste has a specific mixture of nano-crystals and micro-powder of nano-structured hydroxyapatite, in a phosphate-buffered saline solution with physiological pH; It is available in a wide range of formats (from 2 cc to 10 cc). To enable precise in situ application, the luer-lock cannula is available for orthopedics and neurosurgery, with a length of 10 cm that can be shortened by cutting.

It is indicated for bone cracks, vertebral cages fillings, comminuted fractures synthesis, and filling of the screw holes following the removal of osteosynthesis metal implants.

NuvaBone Mouldable Crunch

The Crunch formulation, with the addition of micro-granules with proper granulometry, shows a higher nano-structured hydroxyapatite density than the injectable paste, resulting in an extremely moldable and stable mixture even in a bleeding environment. The open-mouth syringes allow for the extrusion of the product in a cylindrical shape, making it easily adaptable to any implantation site.

It is available in a wide range of formats (from 2 cc to 10 cc) and is indicated for filling cavitary and non-cavitary bone defects in orthopedics and traumatology. It is also indicated for spinal cages fillings (even extensively fenestrated) in spinal fusions, and arthrodesis.


  • Complete biocompatibility
  • Highly porous and interconnected structure to support optimal osteoconduction
  • High surface/volume ratio for a better biological response
  • Excellent chemical-physical stability
  • Complete remodeling in physiological times